Abstract The columellar muscle (foot-shell retractor) of the intertidal limpet Collisella digitalis is responsible for the tenacity with which this limpet can hold onto rock substrate in response to mechanical stress (i.e. wave action and predation) (Fretter, 1962). Consequently, dessication and splash provide great osmotic stress upon this intertidal limpet. This paper describes the varying excitability and "catch" characteristics of the foot-shell retractor muscle under varying osmotic stresses. INTRODUCTION Causes of intertidal zonation for Collisella digitalis and other Collisella (formerly Acmaea; Lindberg, 1981) of the Central California Coast have been shown to result from physical as well as biological "limiting factors." The upper limiting factors for C. digitalis are set by dessication and temperature tolerances (Carefoot, 1977, Wolcott, 1973). Lower limiting factors are traditionally thought to be set by biological factors. These include competition for space and food resources (Haven, S.B. 1973, 1971) as well as behavioral limitations (Wolcott, 1973). Thus, physical limiting factors have often been cited in the literature for limiting upper distribution but apparantly not so for the lower distribution of C. digitalis. Many recognize this developing concept, that the upper limits of distribution are physically determined and lower limits determined by biological factors (Carefoot, 1973, Connell, 1961). Physically determined lower limits of distribution, however, could affect C. digitalis. Experiments reported in this paper were designed to investigate the osmotic stress C. digitalis experiences during low tide dessication and high tide submersion. The indices of stress used were contractile properties of the shell-foot retractor muscle under varying osmotic conditions. This muscle, also called the columellar muscle, is used by the limpet to hold tenaciously onto rock substrates and must be largely responsible for the animal's ability to live in exposed areas experiencing great wave action. This muscle is also responsible for the shell clamp-down behavior which provides protection from predators (Fretter, 1962). MATERIALS AND METHODS Specimens were collected from the intertidal zone at Cabrillo Point, Pacific Grove, California, in the afternoon just before high tide to ensure that the limpets had been subject to several hours of natural dessication stress prior to study. Three groups were established. The first was placed in sea water for five hour to induce isoosmotic conditions simulating coverage by waves and splash during the high tide cycle. After the five hour soak period the limpets were removed, and osmolalities of the extra-corporeal fluid were measured by extraction of fluid with a 20 gauge syringe and determination by a freezing-point depression osmometer. These animals constituted the "full recovery" group. The foot-shell columellar muscle was excised in sections of 3x 1 mm, with both ends intact, and mounted for shortening experiments in which muscles were stimulated with single, repetitive, electrical shocks. The electrode consisted of two 3x 4 pieces of platinum foil coated with platinum black. Electrodes were positioned tranversely within 0.5 mm of the muscle. Electrode pulses were provided with a Grass S44 stimulator. Shortening (under (1 gram of load) was measured with a Phipps and Bird Displacement Transducer model ST-2 and recorded with a Brush Recorder Mark 280. For the second and third groups extra-corporeal fluid osmolality was measured immediately after removal from intertidal sites. Muscles were excised and studied in a manner similar to the first group. Note that limpets in the second group were bathed in sea water only for the duration of the experiment and were designated the "No Recovery" group. The third group was bathed in hypertonic sea water (1300 mosm) corresponding to the osmolalities of the animals in the field (1200-1400 mosm). Hypertonic sea water was prepared with 14.61 g Nacl in one liter sea water then diluted with sea water until osmolality reached 1300 mosm. This last group was termed the "Hyperosmotic" group. Results Threshold Twitch Behavior Muscles from each group studied, "Full Recovery (Full R), No Recovery (No R), and Hyperosmotic (Hyp)," respond to a single, brief (0.5 ms) electrical shock (10 V) with a slow twitch. Time to peak was approximately 3-5 sec and time to half-relaxation 8-14 sec. Amplitudes of these near threshold twitches are specific for the different groups of muscles. Responses, measured inmm shortened, are compared in Figure 1 for single 10 V shock with durations varying from 0.5 to 2.0 msec. The Full R group produced the largest twitches. Comparatively smaller twitches were recorded from the No R group, and the smallest twitches from the Hyp group. Figure 2 shows results of an analogous experiment employing 20 V shocks. Twitches for all groups are larger than those elicited by 10 V stimuli. Again the Full R group showed greater shortening response than the other groups. With larger auochs, reugenses of the No R and Ryp groups were not distinguishable from one another. Figure 3 illustrates shortening recordings of the three groups during tetanic stimulation with 20 V shocks at 200 Hz. Time to maximal shortening ranged from 16 sec to 70 sec for the three groups. Muscles responded with greatest peak shortening in Full R, but amplitudes were not as distinct from No R and Hyp group amplitudes as amplitudes were in response to single shocks. Time to peak did not differ. Relaxation times were very different (see Figure 3). Results are supported by other experiments and provided in summary Table 1. Table 1 shows the mean times for maximum shortening, time to peak, time to half-relaxation and relative osmolarity measurements. Mean times to half-relaxation are very significant and reveal great disparity between the three groups. Muscles studied in the hypertonic medium clearly relax from tetanic stimulation more slowly than muscles from the other two groups. Discussion The differential responses to varying osmotic conditions may indicate a physical limit on the lower distribution of C. digitalis. The reasoning behind this idea will be discussed. Single shock twitches revealed decreased contractility for muscles subject to high osmotic conditions. Hyp muscles showed markedly lower twitching in response to even the smallest stimuli, compared to No R and Full R groups. Specifically No R muscles (prepared in a manner identical to Hyp muscles (1300 mosm) only being bathed in sea water (970 mosm)) showed decidedly higher sensitivity to single 10 V shocks. Based upon these results a limpet's ability to forage and move locations is likely to be reduced under dessication stress. At the same time, under near isoosmotic conditions (to sea water) limpet muscle has a greater ability to shorten. Applied to field situations, this suggests greater movement or greater ability for movement under near isoosmotic conditions such as found during high tide compared to low tide dessication. From behavioral studies it is known that C. digitalis moves actively during high tide. Consequently, decreased ability for muscle shortening induced by hyperosmotic conditions tested in this study corresponds to clumping behavior and decreased movement observed in the field during low tides. The extent to which behavior is influenced by physiologically suppressed or enhanced muscles is as yet undetermined and deserves additional study. Tetanic Responses Tetani were elicited at shock frequencies of 200 Hz. There were noted differences between the groups. Maximum shortening responses revealed that the Full R group shortened the most relative to Hyp group shortening, with the No R Group shortening least of all. However, this pattern cannot be regarded as unequivocal due to shortening response being dependent upon size of limpet tested and due to variability with a small sample size (n-tetanic - 2/group). Thus although the degree of muscle shortening may be osmotically dependent, this report cannot conclusively determine this relationship. Mean times to peak were recorded during the period of 25 to 33 sec beginning from time of stimulation. Averages of these data fail to show any significant differences between the groups. The greatest difference in the three groups lies in the muscles ability to maintain the shortened state following tetanic stimulation. The osmotically stressed group, Hyp, revealed a far greater ability to maintain a sustained shortened position than either of the other two groups. This difference amounted to an approximately sixteen-times slower rate of re-extension than for the lowest osmotically stressed group, Full R. Hore work is needed to clarify results concerning the time to peak and maximum shortening response by increasing the number in each sample group. Further, varying osmolality using a variety of agents in addition to NaCl will better characterize the muscle. Although force was not measured in the present study, it is tempting to speculate that the slow rate of re-extension is analagous to the molluscan "catch" response, in which a muscle can maintain force for a very long time in the absence of continued stimulation (Twarog, 1967). Thus re-extension responses, following tetani in the three groups studied may indicate that osmotic conditions are an important factor in maintenance of the "catch" state. If these assumptions are accepted, then limpets in the near isoosmotic condition (to sea water) of being "Fully Recovered" show a much weaker ability to maintain long catch" states. Conversely, dessicated animals would find it much easier to maintain a catch state for long periods and to maintain a firm hold on a rock. These effects of osmolality on limpet muscle suggest that limiting factors C. digitalis encounters in the field could influence distribution limits. Not only can the limpet be restricted by upper physical boundaries due to dessication and heat stress, but may also experience lower physical boundaries in addition to the many biological boundaries. Intriguinaly. this lower physical limit might involve physiological alterations such as reduced ability to maintain muscular catch associated with body fluid osmolalities (isoosmotic with sea water) under high tide conditions. References Carefoot, T. Pacific seashores; a guide to intertidal ecology. Seattle: University of Washington Press, 1961. Connell, J.H. (1961). The influence of interspecific competition and other factors on the distribution of the barnacle Chathamalus stellatus. Ecology. 42:710-723. Fretter, V. a Graham, A. British prosobranch molluses; Their functional anatomy and ecology. London:Ray Society, 1962. Haven, S.B. (1971). Niche differences in the intertidal limpets, Acmaea scabra and Acmaea digitalis (Gastropoda) in central California. Veliger. vol. 13, no. 3. Haven, S.B (1973). Competition for food between intertidal gastropods, Acmaea scabra and Acmaea digitalis. Ecology. 54(1):143-151. Lindberg, D.R. Acmaeidae: Gastropoda mollusca. Pacific Grove, California: Boxwood Press, 1981. Iwarog, B.M. (1967). Factors influencing contraction in catch in Nytilus smooth muscle, J. Physiology. 192 (3):847-856. Wolcott, T.G. (1973). Physiological ecology in intertidal zonation in limpets (Acmaea): a critical look at "limiting factors. Biol. Bull. 145. Figure Legends Figure 1. Excitability varies with osmolality. Figure 1 represents displacement (mm) versus duration (ms) at 10 V shocks. Note the greater shortening excitability of f-rec to n-rec and h-osm. Figure 2. Excitability varies with osmolality. Figure 2 represents displacement (mm) versus duration (ms) at 20 V shocks. Note the greater shortening of f-rec to n-rec and h-osm. Figure 3. Hyperosmolality enhances long catch responses. Comparison of peak to half-relaxation records for the three groups (pulse times are specific for the individual traces). Shortening measurements are mean values of all members in the separate groups. Note the great differences in half-relaxation time for the varying osmolality groups (see Table 1). Table 1. Comparitive table of the mean values of shortening responses and tetanic shortening characteristics of each group compared with mean osmolality values of extra-corporeal fluid. Most important values are the Times to Half-relaxation. i o 15 1 )( O 8 i 5 88 MAXIMUM SHORTENING (mm) TIME T PEAK (sec) TIME TO HALF RELAXATION OSMOLARITY (mosm) FULL RECOVERY 1.41 f .62 25.3 - 11.3 19.2 min. f 11.97 956.3 + 6.75 NO RECOVERY HYPEROSMOTIC (1300mosm) 98 + .95 1.37 33.0 + 6.98 24.5 48.5 min. 307.9 min. f 18.74 1400 + 29.14 1385