ABSTRACT: Mytilus californianus dominates the rocky mid-intertidal zone along much of the West Coast of North America from Alaska to Baja California. Thus, it has important effects on community structure. Previous work has failed to identify genetic differences among populations along this latitudinal gradient. However, some differences in morphology have been described. A preliminary study showed that mussels from Central Oregon grew significantly faster than those from Central California when transplanted to sites in either state. My study investigated physiological differences in populations of M. californianus from Oregon and California. In February, mussels were transplanted to California from Oregon and California. In May, additional mussels were freshly collected from the original populations. Gill respiration rates and malate dehydrogenase (MDH) activity were examined to compare metabolic rates of individuals in these populations, and determine if differences were intrinsic or transitory effects of acclimation. No significant differences were found in respiration rates or MDH activity between the two populations of mussels, both for field acclimated and freshly collected groups. Although overall field growth was low, there was suggestive but inconclusive evidence that transplanted mussels from Oregon grew significantly more than California mussels during the February to May period. These results do not rule out either an acclimation effect or intrinsic differences between these populations. Because the Oregon waters were slightly colder (by 2.5°C) during the ten weeks prior to the transplantation. acclimation of the Oregon mussels may explain the growth difference. Alternatively. there could be intrinsic differences in growth potential between the two populations. In either case, differences in respiration rates and MDH activity were either too small to be detected, or may not be directly correlated with growth activity. Although physiological differences were not observed, there appear to be some differences among these mussel populations such as the average dry weight of gills from Oregon mussels was 16.9% less than the average weight of similarly sized California mussels. INTRODUCTION Although intertidal and subtidal systems have been studied extensively, very little is known regarding latitudinal variation in marine populations. Considerable research has found physiological and biochemical variation in organisms across their geographic range (Walsh and Somero 1981, Hochachka and Somero, in press), but little is known about how these responses to local temperature affect populations and communities. In addition to differences caused by the latitudinal temperature gradient, populations may vary genetically. The life histories of most marine species include planktonic stages, and thus high gene flow among populations is expected. However, current studies suggest that larval retention and genetic differentiation may be more common than previously thought (Warner et al. 2000). Recent work has found significant differences in growth between mussels from populations of Mytilus californianus. During the summer of 2000, Eric Sanford transplanted groups of mussels from Central Oregon and Central California to both Oregon and California. The results showed that Oregon mussels grew faster than those from California at all sites independent of location. In this study, I investigated whether differences between populations were the result of acclimation or intrinsic effects. The California mussel, M. californianus, is a common marine invertebrate in the rocky mid-intertidal zone (Gosling 1992). Its distribution spans the West Coast of North America from Alaska to Baja California, and often can dominate very wave exposed areas (Ricketts et al. 1985). M. californianus has been shown to limit biodiversity of sessile marine invertebrates through competition for space (Paine 1966). However, the mussel bed creates habitat for other marine organisms. Thus, this species has strong impact on community structure in the intertidal zone. Because M. californianus is an ectothermic species, its body temperature is dependant upon its environment (Helmuth 1999). Therefore, physiological processes could be greatly affected by ambient temperatures. If enzymatic activities of animals are measured at the same temperature, the organisms from colder temperatures will often have higher activities and metabolism than their equivalents from warmer environments (Hochachka and Somero, in press). Thus, the metabolic activities of the organisms at their respective native habitats will be similar. Moving an organism from colder to warmer waters may cause physiological processes to speed up until the animal has acclimated to the new environment. Because the only direct way to quantify metabolism is by difficult calorimetric methods, indirect methods generally are used to measure metabolism (Schmidt-Nielsen 1997). The most used method to obtain metabolic rates is to determine oxygen consumption. Quantifying activity of an ATP generating enzyme is another way to measure metabolism. Metabolism has been correlated with growth (Frandsen and Riisgard 1997), reproduction (Smaal et al. 1997), seasonal variation (Hatcher et al. 1997), age (Sukhotin and Pörtner 2001) and many other processes. Despite the broad distribution of M. californianus, research has shown few significant differences among populations of the mussel. Grant Pogson at University of California, Santa Cruz has not found significant genetic differences among M. californianus populations (Sanford pers. comm.). Levinton and Suchanek (1978) also found minimal genetic variation in M. californianus along 3000km of the North American West Coast. However, M. californianus is known for having variation within a population. Although few growth studies have been done on M. californianus, the rate of shell growth has been shown to vary with age, sex, temperature and food concentration (Coe and Fox 1942, 1944; Fox and Coe 1943). Dehnel (1956) examined growth in the field of mussels from different latitudes, and found significant variation with mussels at his most southern site having the largest growth rate. Unfortunately, mussels at these sites were from different tidal heights, which probably affected growth more than water temperature. Pickens (1965) showed some temperature compensation for the heart rate of M. californianus at colder temperatures. Mussels acclimated to new temperatures in six weeks or less, but this was dependant on mussel size. Additionally, morphological differences between populations have been researched. Environmental conditions (e.g. wave exposure) affect shape and shell thickness, and the thicker shelled mussels may grow slower than thinner ones (Fox and Coe 1943; Coe and Fox 1944). Rao (1953) found an increasing proportion of shell weight to soft tissue weight as latitude increased. This study investigated whether differences in growth between populations of M. californianus from Central Oregon and Central California occurred during the winter period. This research also examined metabolic rates by comparing respiration and malate dehydrogenase (MDH) activity between these two populations. Additionally, some aspects of mussel morphology were evaluated. MATERIAL AND METHODS Collection and Maintenance of Specimens In February 2001, mussels (4.5-5.Scm in shell length) were collected from the lower limit of wave-exposed mussel beds at Mal Paso Creek, California (36°33'N 121°56’W) and Fogarty Creek, Oregon (44°50’N 124°03’W). Mussels from each site were transplanted by Sanford into 20 x 20 cm Vexar"M mesh cages in the low-intertidal zone at two wave-exposed sites: Soberanes Point, California (36°27’N 121°56’W) and Hopkins Marine Life Refuge, California (36°37.3N 121°54.3’W). Each of the six cages contained 20 mussels from both sites of origin. A small notch was filed into the growing lip of each mussel shell to allow the measurement of growth and to identify the source of the mussels (Oregon=1 notch, California=2 notches). In May 2001, transplanted mussels (n=2 per site of origin per cage) were collected at Soberanes Point and put into seawater tanks at Hopkins Marine Station. During the same period, mussels were freshly collected from Mal Paso Creek and Fogarty Creek (n-30 per site) and stored in the same seawater tank. I quantified respiration rates of and enzyme activities in the gills of these mussels. For each mussel, length and growth (of the transplants) were measured. 1 then dissected the mussel and removed both gills, which were washed in 0.22um filtered seawater containing the antibiotics (Penicillin-G and Streptomyocin each at a concentration of 0.15mg/L). For each mussel, one gill was used to obtain a respiration rate and the other was used to determine the activity level of malate dehydrogenase MDH, an enzyme of the Krebs citric acid cycle and the anaerobic glycolytic pathway. Respirometry Before the respiration trial, I put the gill in a 100mL beaker with filtered seawater and antibiotics and placed it in a 15°C water bath. The oxygen microelectrode (model MI-730, oxygen meter model ÖM-4, Microelectrodes, Inc., Bedford, NH) was zeroed by submersing it in an oxygen-free solution of O.OIM NaB saturated with NaS crystals. The electrode was then calibrated to full oxygen saturation in the solution of filtered seawater and antibiotics that was gently bubbled with an air pump. Respiration was measured in a water-jacketed 14.4mL chamber (Fig. 1). The microelectrode entered the chamber through a threaded hole in the top. The water-jacket surrounding the respiration chamber was connected to a water bath set to 15°C and the whole device sat upon a stir plate. The gill was sandwiched between two layers of nylon mesh and placed on a perforated plastic platform over a magnetic stir bar. I carefully sealed the chamber and removed all air bubbles before beginning the trial. Using the Powerlab unit (8sP ADInstruments, Mountain View, CA) and the Powerlab Chart Program, I measured the decline of oxygen saturation for 30 min, removed the gill, and ran a control for another 10 min. Äfter the run, I weighed the gill by blotting both sides with a Kimwipe'" so that respiration rate could be normalized by the mass of the gill tissue. 1 determined gill respiration rates in at least six mussels from each treatment (n-6- 7 per treatment). 1 calculated respiration rates from the slope of the decline in oxygen for 20 min after an initial 10 min period. Because the slope used was after the first 10 min, control runs were not subtracted out since they usually were made during the initial 10 min of the run when there was often noise in the reading. This slope was normalized by incorporating the solubility of oxygen, the volume of the chamber and the weight of the gill. I used the following equation to get the rate in umol O2/sec/gram of gill tissue: (the volume of the chamber) x (slope/100) x (solubility of oxygen at 15°C, latm, 34%00 salinity of seawater). I performed a single factor Analysis of Variance test (ANOVA) to determine whether oxygen consumption differed among the four groups. MDH Biochemical Assay MDH activity was quantified in the other gill from each mussel used in respiration, and from three or four more mussels per treatment (n=10 total per treatment) The gill was weighed and then homogenized (Duall, Kontes Glass Co., Vineland, NJ) on ice by hand and diluted 5x in 200mM imidazole buffer, pH=7.0. I then transferred this solution into a 2mL Eppendorf tube and centrifuged it at 5°C and 1400Orpm for five min, 1 mixed 50mL of 200mM imidazole buffer (pH=7.0) in an Erhlenmeyer flask with 0.0054g of NADH (final concentration of O.15mM) and 0.0014g of oxaloacetate (OAA) (final concentration of O.2mM). This solution was kept on ice and in the dark whenever possible to minimize degradation of NÄDH. A spectrophotometer (UV-1601, Shimadzu Scientific Instruments, Inc., Columbia, MD) with the Kinetics computer program was used to read the activity of the enzyme. The spectrophotometer was zeroed using the buffer before assays were started. 3mL cuvettes with 2mL of the cocktail were equilibrated in a 15°C water bath. Using a 25uL Lang-Levy pipette, I transferred an aliquot of the sample to one of the pre-equilibrated cuvettes in the spectrophotometer, stirred the solution vigorously for five seconds, and then recorded the activity for 30 sec (n=5 replicates per gill). To prepare the measurements for data analysis, I first ensured that the MDH run contained no electrical spikes for at least 15 sec. I calculated the enzyme activity from the change in absorbance/min for 25 sec. To determine the activity of the enzyme the following equation was used: (Aabs/min x volume of gill homogenate)/(s of NADH). where s equals the extinction coefficient. To determine the activity in umol OAAlmin/gram of tissue the activity was multiplied by 200 because 5mg of tissue were put into the cuvette. I performed a single factor ANÖVA to test whether differences in activity existed among the four groups. Respiration rates were compared to the MDH activity using a regression analysis. Morphological Measurements Morphological measurements were also made to investigate variation between the Oregon and California mussels. I measured the shell length, width and total thickness of freshly collected mussels from Oregon and California (n=10 per population). I also measured both wet and dry weights of the gills. Prior to weighing, wet gills were blotted (see above), and dry weights were measured after gills had been dried at 70°C to a constant weight (approximately 48 h). I performed analyses using t-tests and regression analysis to determine if any differences between populations were significant. Field Growth Measurements The growth of transplanted mussels was quantified in late May in the field at both Soberanes Point and Hopkins Marine Life Refuge. New shell added beyond the notch in the growing lip of each mussel was measured (+0.01) using digital calipers. Six cages at Soberanes Point and three cages at Hopkins Marine Life Refuge were sampled (n=30-40 mussels per cage). Using t-tests, I tested whether growth per 100 d differed between mussels from Oregon and California. Temperature Loggers Temperature records were obtained from mid-intertidal data loggers (Optic StowAway, Onset Computer Corp., Pocasset, MA) at Soberanes Point, Hopkins Marine Life Refüge, and Fogarty Creek. Data loggers were put in the field over three months before the February transplantation and were collected in May after samples were taken. I used the temperatures from two hours before to two hours after each high tide to calculate the mean high tide temperature. These data were used to estimate the acclimatization temperature of the mussels used in this study. In addition, data on temperatures while the transplants were in the field were collected. Data were analyzed using a t-test to determine if the sites had different temperatures. RESULTS Four treatment groups were compared: freshly collected from Oregon and California, and field-acclimatized from Oregon and California (transplanted for 10 weeks to Soberanes Point). Respirometry The respiration runs showed great variability among individuals within the same treatment group (Fig. 2). Mussels in all treatments had similar respiration rates of approximately 0.0012 +0.0001 umol O2/sec/gram of tissue. There were no significant differences between the Oregon and California mussels, either freshly collected or field acclimated (Table la, ANOVA, p-O. 413). MDH Biochemical Assay Similar to the respiration results, the MDH activity showed no significant differences among the treatment groups (Table 1b, ANÖVA, p-O. 831). There was considerable variability among individuals, but replicates for each individual were very similar. The mean activity for all treatments were very similar at 0.143+ 0.005 umol OAA/min/gram of tissue (Fig. 3). There was no correlation between respiration rates and MDH activity levels (Fig. 4, p-0.194, R“=0.075). Morphological Measurements The thickness (t,=-0.828, df=18, p=0. 419), length (t,=-0.263, df-18, p-0. 796), and width (t,=1.23, df=18, p=0. 235) of the shell were not significantly different between Oregon and California mussels. However, despite the similar size of mussels, the gill dry weight of Oregon mussels was 16.9% less than that of California mussels (0.0190g vs. 0.0229g, respectively; t,=2.66, df=18, p=0. 016). Gill wet weight was significantly correlated with gill dry weight (Fig. 5, p=1.68E-06, R“=0.729). In addition, I noticed that the Oregon mussels had pale gills while the California mussels' gills were bright and rich in color (Fig. 6). Field Growth Measurements At both sites, the mussels from Oregon grew faster than those from California (Fig. 7), although differences fell just short of statistical significance. At Hopkins Marine Life Refüge, the Oregon average growth was 1.72mm/100 d while for California mussels it was 0.952mm/100 d (t==-0.196, df=4, p=0.061). Similarly, at Soberanes Point, Oregon mussels tended to grow faster than those from California (0.52mm/100 d vs. 0.31mm/100 d, respectively) although growth was much lower than that at Hopkins, and the difference was only marginally significant (t,=-1.739, df-10, p-0.056). Temperature Loggers Water temperatures during the 10 weeks prior to the February transplantation of the mussels were 2.5°C cooler at Fogarty Creek than at Soberanes Point (Fig. 8, t,-30.04, df-292, p=2.64E-91). In contrast, water temperatures during the 10 weeks prior to collection of fresh mussels in early May were only 0.7°C cooler at Fogarty Creek (Fig. 9. ts=1.969, df=254, p=4.94E-04). Mussels transplanted to Soberanes Point experienced water temperatures 2°C cooler than those at Hopkins Marine Life Refuge during the 10 weeks of growth (Fig. 9, t,=15.83, df=254, p=9.48E-40). DISCUSSION This research showed that during the winter, growth of Oregon and California M. californianus was very slow. The difference in mussel growth rate was nearly significant between the populations (p=0.05-0.06), but the lack of significance in rates may be due to small sample sizes and low resolution from little growth. In comparison with a similar study during the summer (Sanford, unpub. data), the summer growth was over 3.5 times faster than the winter growth for these populations of M. californianus. Acclimatization has been hypothesized as one of the reasons that mussels from Oregon grow faster than the mussels from California. During the February transplantation, the Oregon mussels were coming from water that was 2.5°C colder (Fig. 8) so that the difference in growth could have been due to acclimation. However, Sanford's study in 2000 that showed a dramatic difference in growth, actually had Oregon mussels being transplanted to a colder climate than what they had experienced (due to earlier onset of spring upwelling in Central California), suggesting that the differences in growth could not have been due to acclimatization. Another interesting finding of my study was that mussels grew faster in Hopkins Marine Life Refuge than ones at Soberanes Point. Hopkins Marine Life Refuge is in Monterey Bay whereas Soberanes Point is on the open coast, where water temperatures are often over 2°C cooler (Sanford, unpub data). Because age can play a role in growth rate, it may also be a factor in why Oregon mussels seem to grow faster. Younger mussels grow faster than older mussels (Morris et al. 1980, Sukhotin and Pörtner 2001). Therefore, if mussels grow faster in Oregon because of another factor such as food availability, then although similarly sized mussels were transplanted, those from Oregon may have been younger. Thus, differences in growth may be the result of the difference in age rather than a true difference between populations. The suggestive difference in growth was not reflected in the physiology of these organisms. Respiration and MDH activity results clearly showed no significant differences between Oregon and California mussels during winter (Fig. 2 and Fig. 3). However, because the growth was minimal, the differences in metabolic rates may have been muted and difficult to detect with relatively small sample sizes. Respiration and MDH activity showed no correlation (Fig. 4). This may be because MDH plays a role in both aerobic and anaerobic ATP generation whereas oxygen consumption only reflects aerobic metabolism. In addition, it is possible that respiration and MDH activity may not be linked with growth in M. californianus. Despite the similarities in physiology, there were some interesting morphological differences. The Oregon gills were much lighter in pigmentation than the California gills (Fig. 6), perhaps due to an environmental factor (e.g. diet) or perhaps indicating intrinsic differences between the populations. In addition, for similarly-sized mussels, the Oregon gill was significantly smaller than the California gill. This, too, could reflect greater water-column food concentration in Oregon (such that the gill needs less surface area), or it may be an intrinsic difference between the populations. The larval biology of M. californianus suggests minimal variation between populations along a latitudinal gradient. The pelagic larval stage of the M. californianus veliger lasts about nine days (Strathmann 1987). Because of the short pelagic larval stage, it seems unlikely that the larvae would be able to travel significant distances along the Northern American West Coast. Thus, populations of M. californianus along the West Coast could have reduced gene flow, and differences in populations especially because of adaptations to a particular environment seem possible. One factor this research did not address was possible differences in air temperature and heat stress between sites. The mussels were normally exposed for about half of the day. Air temperature in Oregon would most likely be colder, but the effects of air temperature on mussel growth, respiration, and MDH activity are unknown. However. air temperature during this winter probably did not reach high enough temperatures to cause any heat stress on the mussels. This research provides a baseline for future work. Äfter a transplant that lasted through winter and summer, the major growth period, the mussels could be measured again. By the summer, any acclimation effect would likely be eliminated (Pickens 1965). and any remaining differences between mussel populations might then reflect genetically fixed differences. Non-genetic factors (e.g. gill size) that were initially set by environment could then have lasting effects, unrelated to thermal acclimation. In addition, the physiological tests could be repeated to show whether growth correlated with respiration and MDH activity during a season of greater growth. Other indicators of growth and physiology could also be used such as heart rate, calorimetry, and RNA:DNA ratios. An enzyme that indicates only aerobic metabolism such as citrate synthase (CS) might be more directly related to oxygen consumption than MDH. To research how temperature changes affect growth, temperature could be directly manipulated in laboratory experiments. The influence of age is another factor that should be examined. By transplanting very young mussels, any age discrepancy would be reduced and observed growth rates may be more reflective of actual population differences. M. californianus is currently thought of as a genetically uniform species despite its broad range in distribution. However, the field growth results of this research and Sanford’s study suggest intrinsic differences between populations could exist. Further research may suggest that M. californianus should be included in a growing body of evidence that marine populations can vary substantially with latitude despite the lack of obvious barriers to dispersal (Warner et al. 2000) ACKNOWLEDGEMENTS Thank you to George Somero, a fantastic advisor who was supportive of almost anything 1 wanted to try in the lab. Peter Field, where would I be without your help with the biochemical assays and for letting me call you at home whenever I ran into a problem. Thanks to Caren Braby who I asked a million questions and for helping me with all the little things. The rest of the Somero lab thanks for helping me out whenever I got stuck on something. I am most grateful to Eric Sanford without whom this project definitely would not have happened. It’s a good thing you set up the whelk experiment in the field otherwise, 1 couldn’t have done this project. Thank you for all the time you spent editing, and re-editing, and re-editing and making my project what it is. Thanks to my parents for all their encouragement to pursue research. Jonah, thanks for everything. LITERATURE CITED Coe, W.R. and D.L. Fox. 1942. Biology of the California sea-mussel (Mytilus californianus). I. Influence of temperature, food supply, sex and age on the rate of growth. J. Exp. Zool. 90: 1-30. Coe, W.R. and D.L. Fox. 1944. Biology of the California sea-mussel (Mytilus californianus). III. Environmental conditions and rate of growth. Biol. Bull. 87: 59-72. Dehnel, P. A. 1956. Growth rates in latitudinally and vertically separated populations of Mytilus californianus. Biol. Bull. 110: 43-53. Fox, D.L and W.R. Coe. 1943. Biology of the California sea-mussel (Mytilus californianus). II. Nutrition, metabolism, growth and calcium deposition. J. Exp. Zool. 93: 205-49. Frandsen, K.T. and H.U. Rissgard. 1997. Size dependent respiration and growth of jellyfish, Aurella aurita. Sarsia 82: 307-213. Gosling E. 1992. Systematics and geographic distribution. pp.1-17 in E. Gosling, ed. The Mussel Mytilus: Ecology, Physiology, Genetics and Culture. Elsevier Science Publishers, Netherlands. Hatcher, A., J. Grant, and B. Schofield. 1997. Seasonal changes in the metabolism of cultured mussels Mytilus edulis L. from a Nova Scotian inlet: the effects of winter ice cover and nutritive stress. J. Exp. Mar. Biol. Ecol. 217: 63-78. Hochachka, P.N. and G.N. Somero. In press. Biochemical Adaptation: Mechanism and Process in Physiological Evolution. Oxford University Press, Oxford. Helmuth, B. 1999. Thermal biology of rocky intertidal mussels: Quantifying body temperatures using climatological data. Ecology 80: 15-34. Levinton and Suchanek. 1978. Geographic variation, niche breadth and geographic differentiation at different geographic scales in the mussels Mytilus californianus and M. edulis. Mar. Biol. 49: 363-375. Morris, R.H., D.P. Abbott, and E.C. Haderlie. 1980. Intertidal Invertebrates of California. Stanford University Press, Stanford, CA. Paine, R. T. 1966. Food web complexity and species diversity. Amer. Nat. 100: 65-75. Pickens, P.E. 1965. Heart rate of mussels as a function of latitude, intertidal height, and acclimation temperature. Physiol. Zool. 38: 390-405. Rao, K.P. 1953. Rate of water propulsion in Mytilus californianus as a function of latitude. Biol. Bull. 104: 171-181. Ricketts, E. F., J. Calvin, and J.W. Hedgpeth. Revised by D. H. Phillips. 1985. Between Pacific Tides. Stanford University Press, Stanford, CA. Schmidt-Nielsen, K.1997. Energy metabolism. Schmidt-Nielsen, K. Animal Physiology, 5“ ed. Cambridge University Press, Cambridge, UK. Smaal, A.C., A.P.M.A. Vonck and M. Bakker. 1997. Seasonal variation in physiological energetcis of Mytilus edulis and Cerastoderma edule of different size classes. J. Mar. Biol. Ass. U.K. Strathmann, M.F. 1987. Reproduction and Development of Marine Invertebrates of the Northern Pacific Coast. University of Washington Press, Seattle. Sukhotin, A.A.and H.O. Pörtner. 2001. Age-dependence of metabolism in mussels Mytilus edulis (L.) from the White Sea. J. Exp. Mar. Biol. Ecol. 257:53-72. Walsh, P.J. and G.N. Somero. 1981. Temperature adaptation in sea anemones: Physiological and biochemical variability in geographically separate populations of Metridium senile. Mar. Biol. 62: 25-34. Warner, R.R. S.E. Swearer, and J.E. Caselle. 2000. Larval accumulation and retention: Implications for the design of marine reserves and essential fish habitat. Bull. Mar. Sci. 66: 821-830. TABLES Table 1a: Single factor ANÖVA test of respiration rates of gills between different treatment groups. Source of Variation MS P-value Between Groups 6.95E-08 0.997487 0.413372 Within Groups 6.97E-08 Total 24 Table 1b: Single factor ANOVA test of MDH activity of gills between different treatment groups. Source of Variation P-valu MS Between Groups 0.000169 0.902587 0.291257 Within Groups 0.000579 Total FIGURE LEGEND Fig. 1. Diagram of the respiration chamber used in this study. Fig. 2. Respiration rates of gills (n=6-7 per treatment) in the four treat groups. Error bars are standard errors of the means. Fig. 3. MDH activity levels of gills (n=10 per treatment). Error bars are standard errors of the means. ig. 4. Correlation of MDH activity and respiration. Fig. 5. Correlation of dry and wet weights of gills. Fig. 6. Photograph of Oregon and California gills. Fig. 7. Winter growth of transplanted mussels (n-3 cages at Hopkins Marine Life Refuge, n=6 cages at Soberanes Point). Error bars are standard errors of the means. Fig. 8. High tide water temperature at Fogarty Creek, OR, Hopkins Marine Life Refuge, CA, and Soberanes Point, CA prior to February transplantation. Fig. 9. High tide water temperature at Fogarty Creek, OR, Hopkins Marine Life Refuge, CA and Soberanes Point, CA prior to May collection of fresh mussels, and prior to recollecting and sampling of transplants. Fig. 1: Respiration Chamber microelectrode water jacket water out stir plate gill mesh package — perforated platform stir bar water in 22 0.0018 0.0016 0.0014 0.0012 0.001 0.0008 0.0006 0.0004 0.0002 u3o ou Fig. 2: Mytilus californianus Respiration Rates California California Oregon Oregon Fresh Fresh Acclimated Acclimated Treatment 23 Fig. 3: Mytilus californianus MDH Activity Oregon Calitomia Oregon California Fresh Acclimated Acclimated Fresh Treatment 24 Fig. 4: MDH vs. Respiration 0.06 0.05 — 0.03 . * * 002 y =0.0004x +0.0232 0.01 R2=0.0754 000 0.00 5.00 10.00 15.00 20.00 25.00 30.00 35.00 40.00 45.00 MDH Activity (umol OAA/min/gram of tissue) 0.25 05 0.05 0 Fig. 5: Dry vs. Wet Weight Mytilus californianus Gills . y = 7.3888x + 0.0308 R2=0.729 0.015 0.02 0.025 0.03 0.035 0.005 0.01 Dry Weight (g) 26 Fig. 6: Variation in Mytilus californianus Gill Coloration Lalise Fig. 7 Winter Variation in Mytilus californianus Growth MMussels from CA HMussels from OR Soberanes Point Hopkins Site 28 Fig. 8: Water Temperature (Dec '00-Feb '01) 13 V Paa- S —Fogarty Creek, OR -Hopkins Marine Life Refuge, CA — - Soberanes Point, CA 29 Fig. 9: Water Temperature (March ’01-May'01) 10 10 a P Date —Fogarty Creek, OR — Hopkins Marine Life Refuge, CA - Soberanes Point, CA 30